Identification of two metabolites of the cholinesterase reactivator HI??6 isolated from rat urine

DA Ligtenstein, ERJ Wils, SP KOSSEN…

Index: Ligtenstein; Wils; Kossen; Hulst Journal of Pharmacy and Pharmacology, 1987 , vol. 39, # 1 p. 17 - 23

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Citation Number: 11

Abstract

Two metabolites, isolated from the urine of rats given the cholinesterase reactivator HI-6 intravenously, still contained quaternary nitrogen atoms and therefore could not be extracted from aqueous solutions by organic solvents. Both metabolites were isolated by preparative high performance liquid chromatography and were identified using mass spectrometry, gas chromatography, infrared spectrometry, ultraviolet spectrometry and proton nuclear ...