Practical Chemo-Enzymatic Process for the Preparation of (1 R, cis)-2-(2, 2-Dihaloethenyl)-3, 3-dimethylcyclopropane Carboxylic Acids

A Fishman, D Kellner, D Ioffe…

Index: Fishman, Ayelet; Kellner, Dorit; Ioffe, David; Shapiro, Evgeny Organic Process Research and Development, 2000 , vol. 4, # 2 p. 77 - 87

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Citation Number: 12

Abstract

A practical chemo-enzymatic process for the preparation of optically active (1 R, cis)-2-(2, 2- dichloro (or dibromo) ethenyl)-3, 3-dimethylcyclopropane carboxylic acids (permethrinic or deltamethrinic acids) from racemic 1, 1, 1-trichloro-2-acetoxy-4-methyl-3-pentene is described. The key intermediate, enantiopure (R)-1, 1, 1-trichloro-2-hydroxy-4-methyl-3- pentene, is prepared by a lipase catalysed kinetic resolution of the racemic acetate. The ...