Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2′-deoxyuridine, 5-iodo-3′-fluoro-2′, 3′-dideoxyuridine, and 3′-fluorothymidine for molecular …

…, E Mack, J Baranowska-Kortylewicz

Index: Kortylewicz, Zbigniew P.; Kimura, Yu; Inoue, Kotaro; MacK, Elizabeth; Baranowska-Kortylewicz, Janina Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2649 - 2671

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Citation Number: 8

Abstract

Targeted molecular radiotherapy opens unprecedented opportunities to eradicate cancer cells with minimal irradiation of normal tissues. Described in this study are radioactive cyclosaligenyl monophosphates designed to deliver lethal doses of radiation to cancer cells. These compounds can be radiolabeled with SPECT-and PET-compatible radionuclides as well as radionuclides suitable for Auger electron therapies. This characteristic provides an ...