A novel series of 2, 6, 7-substituted 2, 3-dihydro-1, 4-benzodioxin and 2, 6, 7-substituted 1, 4-benzodioxin derivatives as lipid peroxidation inhibitors. Structure-activity …

…, JG Bizot-Espiard, B Pfeiffer, P Renard…

Index: Thiery; Coudert; Bizot-Espiard; Pfeiffer; Renard; Lindenbaum; Guillaumet Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3904 - 3914

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Citation Number: 11

Abstract

A series of 6-or 7-substituted 2-carboxamido-or 2-(aminomethyl)-1, 4-benzodioxin and-2, 3- dihydro-1, 4-benzodioxin derivatives were synthesized and evaluated to determine the necessary structural requirements for a high inhibition of human low-density lipoprotein copper-induced peroxidation. The most active compounds (21, 25, 28, 36, and 37) were found between 5 and> 45 times more active than probucol itself. Due to both their potency ...