Synthesis of 3′??amino??3′??deoxyadenosine 5′??triphosphate
…, C Schattenkerk, JH van Boom
Index: Visser, G. M.; Schattenkerk, Cecile; Boom, J. H. van Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 5 p. 165 - 168
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Abstract
Abstract Phosphorylation of 2′-O-acetyl-3′-(trifluoroacetamido)-3′-deoxy-N 6- benzoyladenosine with 1, 1′-[(4-morpholinyl) phosphorylidenedi-oxy] bis-1H-benzotriazole gives a fully protected intermediate. The latter, after removal of the benzotriazolyl group from the 5′-phosphotriester function, can be converted by the addition of pyrophosphoric acid, followed by the removal of all protecting groups, into ATP (3′ NH 2).
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