Stereochemical control of biocatalytic asymmetric reduction of diethyl 2-oxopropylphosphonate employing yeasts

…, M Klimek-Ochab, P Kafarski, B Lejczak

Index: Zymanczyk-Duda, Ewa; Klimek-Ochab, Magdalena; Kafarski, Pawel; Lejczak, Barbara Journal of Organometallic Chemistry, 2005 , vol. 690, # 10 p. 2593 - 2596

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Citation Number: 22

Abstract

Nonracemic diethyl 2-oxopropylphosphonate of R and S configuration and of high enantiomeric purity was obtained by stereocontrolled bioreduction using: Rhodotorula rubra, Rhodotorula glutinis, Rhodotorula gracilis and baker's yeast. The effect of the addition of chemical compounds influencing the stereoselectivity of biotransformation have been investigated.