Unsaturated macrocyclic lactone synthesis via catalytic ring-closing metathesis 1

KE Litinas, BE Salteris

Index: Litinas, Konstantinos E.; Salteris, Basil E. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2869 - 2872

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Citation Number: 19

Abstract

Ring-closing metathesis (RCM) of the terminal diene esters 2a, b with the Ru catalyst 1 results in the formation of the 20-, 21-membered macrolactones 3a, b in high yields. RCM of the diene oleate esters 4a, b with 1 gives the 19-, 20-membered macrolactones 5a, b in good yields, while an analogous reaction of the diene β, γ-unsaturated ester 6a gives the 13- membered lactone 7a in low yield.