Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide

C Saotome, Y Kanie, O Kanie, CH Wong

Index: Saotome, Chikako; Kanie, Yoshimi; Kanie, Osamu; Wong, Chi-Huey Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 9 p. 2249 - 2261

Full Text: HTML

Citation Number: 48

Abstract

Glycosyltransferases and glycosidases are important classes of enzymes responsible for the synthesis and degradation of oligosaccharides. 1 Development of specific inhibitors of such enzymes is of current interest as these inhibitors may be used as modulators to control cellular functions. Enzymatic hydrolysis of a glycosidic bond generally takes place via general acid and base catalysis that requires two critical residues, a proton donor and a nucleophile (Fig. ...