Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand

…, AP Kozikowski, S Wang, S Pshenichkin…

Index: Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606

Full Text: HTML

Citation Number: 28

Abstract

The synthesis of the 1-benzyl derivative of (2R, 4R)-4-aminopyrrolidine-2, 4-dicarboxylic acid (1-benzyl-APDC) starting from cis-4-hydroxy-D-proline is disclosed together with a study of the activity of this compound at metabotropic glutamate receptors (mGluRs). The compound was found to display good mGluR6 selectivity, and may thus be a useful pharmacological research tool.

Related Articles:

Synthesis and metabotropic glutamate receptor antagonist activity of N 1-substituted analogs of 2R, 4R-4-aminopyrrolidine-2, 4-dicarboxylic acid

[Valli, Matthew J.; Schoepp, Darryle D.; Wright, Rebecca A.; Johnson, Bryan G.; Kingston, Ann E.; Tomlinson, Rosemarie; Monn, James A. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1985 - 1990]

More Articles...