Bioorganic chemistry

New series of 6-substituted coumarin derivatives as effective factor Xa inhibitors: Synthesis, in vivo antithrombotic evaluation and molecular docking

KM Amin, NMA Gawad, DEA Rahman…

Index: Amin, Kamelia M.; Abdel Gawad, Nagwa M.; Abdel Rahman, Doaa E.; El Ashry, Mohamed K.M. Bioorganic Chemistry, 2014 , vol. 52, p. 31 - 43

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Citation Number: 10

Abstract

Abstract Despite recent progress in antithrombotic therapy, there's still an unmet medical need for safe and orally available anticoagulants. Encouraged by the marked antithrombotic and anticoagulant activities of some coumarin derivatives, twenty-three new N-coumarinyl-4- amidinobenzamides 4a–f and 6-heterocycle substituted coumarin derivatives 5, 6a, b, 10a– e, 12a–e and 14a–d were synthesized and evaluated for their in vivo antithrombotic ...