Synthesis and anti-myxovirus activity of some novel N, N′-disubstituted thioureas

…, AE Papadaki-Valiraki, EC Filippatos, S Ikeda…

Index: Todoulou; Papadaki-Valiraki; Filippatos; Ikeda; De Clercq European Journal of Medicinal Chemistry, 1994 , vol. 29, # 2 p. 127 - 131

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Citation Number: 55

Abstract

Abstract A series of new N, N′-disubstituted thioureas were prepared and evaluated in vitro for their activity against myxoviruses. Compound N-[4-(3-propoxy-1H-1, 2, 4-triazol-1-yl) phenyl]-N′-(2-pyrazinyl) thiourea 5d exhibited specific activity against respiratory syncytial virus in HeLa cells. Compounds N-(1-adamantanyl)-N′-[4-(3-ethoxy-1H-1, 2, 4-triazol-l-yl) phenyl] thiourea 5g and N-(1-adamantanyl)-N′-[4-(3-propoxy-1H-1, 2, 4-triazol-1-yl) ...