A formal synthesis of aplysiatoxin: enantioselective synthesis of Kishi's aldehyde
…, S Kuroda, S Ikegami, K Tomita, Y Sugimoto…
Index: Okamura, Hiroaki; Kuroda, Satoru; Ikegami, Satoru; Tomita, Kenji; Sugimoto, Yu-ichi; et al. Tetrahedron, 1993 , vol. 49, # 46 p. 10531 - 10554
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Citation Number: 21
Abstract
This paper describes the enantioselective synthesis of key fragments (12, 18, 24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2). Since 2 has already been transformed into 1a in a short step, its synthesis constitutes a formal total synthesis of 1a Synthesis of fragments of aplysiatoxin (1a) and their convergent assembly to the key intermediate, Kishi's aldehyde (2), for the ...
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