Chemical communications

Synthesis, stability and optimized photolytic cleavage of 4-methoxy-2-nitrobenzyl backbone-protected peptides

ECB Johnson, SBH Kent

Index: Johnson, Erik C. B.; Kent, Stephen B. H. Chemical Communications, 2006 , # 14 p. 1557 - 1559

Full Text: HTML

Citation Number: 10

Abstract

Backbone protection has been shown to increase the efficiency of stepwise chain assembly for the solid phase synthesis (SPPS) of certain aggregating peptides. 1 Backbone modification has also been shown to enhance the solubility of sparingly soluble peptides by disrupting H-bond driven aggregation, and thus disfavoring the aggregated state. 2–4 Because beta-sheet formation is mediated by inter-strand hydrogen bonding between the backbone carbonyl oxygen ...