Synthesis and biological activity of (3, 5??disubstituted??1H??1, 2, 4??triazol??1??yl) benzophenone derivatives

K Hirai, H Sugimoto, T Ishiba, T Fujishita…

Index: Hirai; Sugimoto; Ishiba; et al. Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 6 p. 1363 - 1369

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Citation Number: 29

Abstract

Abstract The synthesis of (5-acylaminomethyl-3-carbamoyl-1H-1, 2, 4-triazol-1-yl) benzophenone derivatives 4a-i, 14a-d, 15a-d, 16a-c, is described. Acylation of the key intermediate, 1-benzoylphenylazo-1-aminoacetamide 7, followed by cyclization in the presence of acid afforded 1H-1, 2, 4-triazole derivatives. These compounds were evaluated for their central nervous system (CNS) activity. Some of these compounds exhibited high ...