Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (Imidazolylbiphenylyl) …

…, R Becker, A Corbier, S Didierlaurent…

Index: Deprez; Guillaume; Becker; Corbier; Didierlaurent; Fortin; Frechet; Hamon; Heckmann; Heitsch; Kleemann; Vevert -; Vincent; Wagner; Zhang Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2357 - 2377

Full Text: HTML

Citation Number: 73

Abstract

The synthesis and pharmacological activity of new potent nonpeptide non-tetrazole angiotensin I1 (MI) receptor antagonists are described. These compounds are 4- thioimidazole derivatives linked on N1 to a biphenylsulfonyl fragment by a methylene spacer. Different acidic sulfonamides such as sulfonylureas 12, sulfonylcarbamates 15, sulfonylamides 16, and sulfonylsulfonamides 17 have been investigated as replacements ...