Concise, flexible syntheses of 4-(4-imidazolyl) pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors
M Toumi, M Barbazanges, SHB Kroll, H Patel, S Ali…
Index: Toumi, Mathieu; Barbazanges, Marion; Kroll, Sebastian H.B.; Patel, Hetal; Ali, Simak; Coombes, R. Charles; Barrett, Anthony G.M. Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6126 - 6128
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Abstract
A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4, 4-dimethoxy-2- butanone and amidines, which provides acetyl-imidazoles and late stage palladium- catalyzed N-arylation to give the target pyrimidine derivatives.
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