Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities

…, TM Robinson, NE Fahmi, F Schmidtmann…

Index: Karginov, Vladimir A.; Nestorovich, Ekaterina M.; Yohannes, Adiamseged; Robinson, Tanisha M.; Fahmi, Nour Eddine; Schmidtmann, Frank; Hecht, Sidney M.; Bezrukov, Sergey M. Antimicrobial Agents and Chemotherapy, 2006 , vol. 50, # 11 p. 3740 - 3753

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Citation Number: 51

Abstract

ABSTRACT Recently, using structure-inspired drug design, we demonstrated that aminoalkyl derivatives of β-cyclodextrin inhibited anthrax lethal toxin action by blocking the transmembrane pore formed by the protective antigen (PA) subunit of the toxin. In the present study, we evaluate a series of new β-cyclodextrin derivatives with the goal of identifying potent inhibitors of anthrax toxins. Newly synthesized hepta-6-thioaminoalkyl ...