Synthesis and immunological activity of 5, 6, 6a, 8, 9, 11a-hexahydronaphth [1', 2': 4, 5] imidazo [2, 1-b] thiazoles and 5, 6, 6a, 9, 10, 11a-hexahydronaphth [2', 1': 4, 5] …

…, Y Kayama, T Watanabe, H Fukushima…

Index: Saito, Masahiko; Kayama, Yasutaka; Watanabe, Tamaki; Fukushima, Hisashi; Hara, Takeshi; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1364 - 1372

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Citation Number: 28

Abstract

A series of 5, 6, 6a, 8, 9, 1la-hexahydronaphth [l', 2': 4, 5] imidazo [2, lb] thiazoles (17 and 20) and 5, 6, 6a, 9, 10, 11a-hexa-hydronaphth [2', 1': 4, 5] imidazo [2, 1-b] thiazoles (18) has been synthesized with cis-and/or trans-1, 2-diamino-1, 2, 3, 4-tetrahydronaphthalenes (12) as the key intermediates and subsequently evaluated for immunological activity (effects on antibody formation and delayed-type hypersensitivity reaction). Among the compounds ...