Synthesis of proline-based diketopiperazine scaffolds

N Deppermann, A Prenzel, A Beitat…

Index: Deppermann; Prenzel; Beitat; Maison Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4267 - 4271

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Citation Number: 13

Abstract

A number of natural products with interesting biological properties are based on a diketopiperazine scaffold. In this context, we have developed a diversity oriented and efficient synthetic strategy to highly functionalized proline-based diketopiperazines. In this paper we describe the stereoselective synthesis of various scaffolds resembling abundant natural product core structures. These scaffolds can be conjugated to a solid phase and ...