Isothiourea??Catalyzed Enantioselective Carboxy Group Transfer

…, CP Johnston, C Concellón, C Simal…

Index: Joannesse, Caroline; Johnston, Craig P.; Concellon, Carmen; Simal, Carmen; Philp, Douglas; Smith, Andrew D. Angewandte Chemie - International Edition, 2009 , vol. 48, # 47 p. 8914 - 8918

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Citation Number: 83

Abstract

The rational design and mechanistic understanding of catalytic systems capable of generating quaternary stereocenters in an asymmetric fashion is a recognized challenge in synthesis.[1] A number of asymmetric Lewis base mediated processes have been developed within this area,[2] in which enantiomerically pure derivatives of 4-(pyrrolidino) pyridine (PPY) and 4-dimethylaminopyridine (DMAP) are elegantly employed by the Fu,[3] ...