Synthesis and Structure-Activity Relationships of New (5R, 8S, 10R)-Ergoline Derivatives with Antihypertensive or Dopaminergic Activity

…, Y ADACHI, K MIZUKOSHI, M NAGASAKA…

Index: Ohno; Koumori; Adachi; Mizukoshi; Nagasaka; Ichihara Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2042 - 2048

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Abstract

A series of new (5R, 8S, 10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were evaluated in conscious spontaneously hypertensive rats and in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra, respectively.(5R, 8S, 10R)-6-Methyl-8-ergolinemethanols, prepared from the corresponding ergolinecarboxylates, were converted to the tosylates, which were ...