Tetrahedron letters

Cobalt-mediated reactions. A new synthetic approach to β-, γ-and δ-lactams

GB Gill, G Pattenden, SJ Reynolds

Index: Gill, G. Bryon; Pattenden, Gerald; Reynolds, Stephen J. Tetrahedron Letters, 1989 , vol. 30, # 24 p. 3229 - 3232

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Citation Number: 61

Abstract

Summary: Unsaturated carbamylcobalt salophens, e. 9.(2), undergo homolytic cleavage (A, sunlamp) producing carbamyl radicals, viz (4) which then undergo cyclisation, accompanied by trapping (with Co II or TEMPO) or dehydrocobaltation, leading to functionalised B-, y-, and 6-lactams eg (31,(61,(8).(111,(13) and (16).