Discovery of 5-chloro-N 2-[(1 S)-1-(5-fluoropyrimidin-2-yl) ethyl]-N 4-(5-methyl-1 H-pyrazol-3-yl) pyrimidine-2, 4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat …

S Ioannidis, ML Lamb, T Wang, L Almeida…

Index: Journal of Medicinal Chemistry, , vol. 54, # 1 p. 262 - 276

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Citation Number: 85

Abstract

... Journal of Medicinal Chemistry. ... or more myeloid lineages. Among these, MF represents the greatest unmet medical need and has been the starting point for clinical trials of Jak2 inhibitors. Typical clinical features of ...