Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3, 4-dihydro-1, 2, 4-benzothiadiazine 1, 1-Dioxide

WJ Close, LR Swett, LE Brady, JH Short…

Index: Close,W.J. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 1132 - 1135

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Citation Number: 30

Abstract

The need for better diuretic and hypotensive agents is attested by the extensive research effort which is being expended in these areas. Although a great variety of drugs is now available to the physician, most of these substances have severe limitations that impair their usefulness. Recently, derivatives of 1, 2, 4-benzothiadiazine I, 1-dioxide have been shown in experimental animals to be carbonic anhydrase inhibitors, and to produce marked One ...