A lymphotropic prodrug of L-dopa: synthesis, pharmacological properties and pharmacokinetic behavior of 1, 3-dihexadecanoyl-2-[(S)-2-amino-3-(3, 4- …

A Garzon-Aburbeh, JH Poupaert…

Index: Garzon-Aburbeh; Poupaert; Claesen; Dumont Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 687 - 691

Full Text: HTML

Citation Number: 81

Abstract

A glyceride derivative of L-Dopa, 1, 3-dihexadecanoyl-2-[(S)-2-amino-3-(3, 4- dihydroxyphenyl) propanoyl] propane-1, 2, 3-triol (l), was synthesized and tested as an orally administrable prodrug endowed with lymphotropic properties. In the oxotremorine and reserpine tests, 1 exhibited an anti-Parkinsonian activity of longer duration than L-Dopa. The time course of concentration of 1 in the intestinal lymph of rat was determined and ...