Alternative and Chemoselective Deprotection of the α??Amino and Carboxy Functions of N??Fmoc??Amino Acid and N??Fmoc??Dipeptide Methyl Esters by Modulation of …
…, A Leggio, A Le Pera, A Liguori, F Perri…
Index: Di Gioia, Maria Luisa; Leggio, Antonella; Le Pera, Adolfo; Liguori, Angelo; Perri, Francesca; Siciliano, Carlo European Journal of Organic Chemistry, 2004 , # 21 p. 4437 - 4441
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Citation Number: 7
Abstract
Abstract The amino and carboxy functions in N-Fmoc-α-amino acid and N-Fmoc-peptide methyl esters can be alternatively and chemoselectively deprotected by treatment with the reagent system AlCl 3/N, N-dimethylaniline (DMA). The chemoselectivity of the process is controlled by modulating the relative molar ratio of the Lewis acid and DMA.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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