Tetrahedron Letters

A practical and scalable process to selectively monofunctionalize water-soluble α, ω-diols

Q Zhang, H Ren, GL Baker

Index: Zhang, Quanxuan; Ren, Hong; Baker, Gregory L. Tetrahedron Letters, 2014 , vol. 55, # 22 p. 3384 - 3386

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Citation Number: 4

Abstract

Abstract A practical protocol for rapid and scalable synthesis of monofunctionalized α, ω- diols using a simple and inexpensive THP ether protection/deprotection strategy was described. Use of inexpensive DHP source and ease to remove excess water-soluble α, ω- diols and THP ether after deprotection render the process scale-friendly without need of column chromatographic separation. The application of present method was also ...