Arzneimittelforschung

Large-scale synthesis of GMP grade N'-[2-(2-thiophene) ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443), a new anti-HIV drug candidate

D DuMez, TK Venkatachalam…

Index: DuMez, Darin; Venkatachalam, Taracad K.; Uckun, Fatih M. Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 6 p. 330 - 338

Full Text: HTML

Citation Number: 2

Abstract

Abstract The thiourea compound N'-[2-(2-thio-phene) ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443, CAS 258340-15-7), was found to be a potent anti-HIV agent with remarkable activity against nucleoside analog reverse transcriptase (NRT)-resis-tant, non-nucleoside analog reverse transcriptase (NNRT)-resistant, as well as multidrug-resistant HIV. Now the method of producing HI-443 under current Good Manufacturing Practice (cGMP) conditions on the ...