Derivation of fluorine??containing pyridinedicarboxylates. III Regio??selective anion chemistry at the 2??and 4??position
JP Chupp, JM Molyneaux
Index: Chupp, John P.; Molyneaux, John M. Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1771 - 1780
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Abstract
Abstract In contrast of Part II of the series, 4-alkyl-2-(difluoromethyl)-6-(trifluoromethyl)-3, 5- pyridinedicarboxylates, 1, were reacted with various strength bases to effect regio-selective reaction of electrophiles at either the benzylic carbanion of the 4-position, or at the 2- (difluoromethyl) carbanion. Weaker bases up to and including potassium butoxide or lithium bis (trimethylsilylamide) effected reaction of 1 at the 4-position to produce 2 and 3 by ...
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[Lee, Len F.; Stikes, Gina L.; Molyneaux, John M.; Sing, Y. Larry; Chupp, John P.; Woodard, Scott S. Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2872 - 2877]
[Lee, Len F.; Stikes, Gina L.; Molyneaux, John M.; Sing, Y. Larry; Chupp, John P.; Woodard, Scott S. Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2872 - 2877]