Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines

N Gouault, M Le Roch, A Cheignon, P Uriac…

Index: Gouault, Nicolas; Le Roch, Myriam; Cheignon, Adele; Uriac, Philippe; David, Michele Organic Letters, 2011 , vol. 13, # 16 p. 4371 - 4373

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Citation Number: 30

Abstract

The piperidine ring is an important structural pattern present in natural and/or synthetic products that display a broad range of biological activities.(1) Therefore, much effort has been devoted to the development of new approaches for its preparation.(2) The use of pyridinones (2,3-dihydropyridin-4(1H)-ones) as versatile intermediates for piperidine synthesis synthesis has attracted significant attention.(3) Many synthetic methods are reported in the literature ...