Tetrahedron Letters

Regioselective assembly of 3, 4-dihydroisoquinoline derivatives

Z Gao, L Davis, Y Chiang, R Munson, JA Hendrix

Index: Gao, Zhongli; Davis, Larry; Chiang, Yulin; Munson, Randall; Hendrix, James A. Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4429 - 4432

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Citation Number: 3

Abstract

A facile two-step sequence (9→ 10→ 1) of regioselective assembly of 3, 4- dihydroisoquinoline derivatives 1 is reported. The halogen derivatives provide opportunity for Suzuki, Buchwald, and related coupling reactions useful for expanding the scaffold and lead optimization in drug discovery.