Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C–H Functionalization/C–N/C–O Bond Formation

MM Guru, MA Ali, T Punniyamurthy

Index: Guru, Murali Mohan; Ali, Md Ashif; Punniyamurthy, Tharmalingam Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5295 - 5308

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Citation Number: 70

Abstract

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper (II)-mediated cascade C–H functionalization/C– N/C–O bond formation under neutral conditions. Substrates having either electron-donating or-withdrawing substituents undergo the cyclization to afford the target heterocycles at ...