Chemistry Letters

Copper (I)-promoted coupling reaction of aryl halides with sodium diethylmalonate

J Setsune, K Matsukawa, H Wakemoto, T Kitao

Index: Setsune, Jun-ichiro; Matsukawa, Kimihiro; Wakemoto, Hirofumi; Kitao, Teijiro Chemistry Letters, 1981 , p. 367 - 370

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Citation Number: 36

Abstract

Copper (I)-promoted coupling reaction of aryl halides with sodium diethylmalonate occurred smoothly in dioxane. The qualitative trends in the activity of copper (I) salt followed the order: CuBr> CuI> CuBF 4 (CH 3 CN) 4> CuCl. The activity was lowered in the presence of coordinating molecule such as acetonitrile, pyridine, NaI, phosphine, and sulfide. The reaction was generally applicable to aryl halides with various substituents.