Nucleosides, Nucleotides, and Nucleic Acids

Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives

GG Sivets

Index: Sivets, Grigorii G. Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 10-12 p. 1237 - 1240

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Citation Number: 3

Abstract

Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2′-O-MOE-purine derivatives is described.