Cytoprotective Effects of 4, 6-Bis (1H-pyrazol-1-yl) pyrimidine and Related Compounds on HClEthanol-Induced Gastric Lesions in Rats.

…, K Maruyama, Y Nobuhara, T YAMADA…

Index: Ikeda, Masazumi; Maruyama, Kazumi; Nobuhara, Youichi; Yamada, Toshihiro; Okabe, Susumu Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 549 - 551

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Citation Number: 18

Abstract

Bis (1H-pyrazol-1-yl)-and bis (1H-imidazol-1-yl) pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4, 6-bis (1H-pyrazol-1-yl) pyrimidine (3) showed a potent inhibitory effect on the HCl· ethanol-, ethanol-, and water immersion stress- induced gastric lesions in rats, and a very low acute toxicity. One of the major factors reponsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. ...