Journal of Fluorine Chemistry

Pd-catalyzed direct arylation of phenylpyrazole: Synthesis of fipronil derivatives with aryl boronic acids promoted by a stoichiometric amount of NIS

T Lv, XH Zhang, JS Han, P Zhong

Index: Lv, Ting; Zhang, Xiao-Hong; Han, Jiang-Sheng; Zhong, Ping Journal of Fluorine Chemistry, 2012 , vol. 137, p. 44 - 49

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Citation Number: 4

Abstract

The palladium-catalyzed direct arylation of phenylpyrazole with aryl boronic acid promoted by a stoichiometric amount of NIS has been reported. Several phenyl pyrazoles, especially for those with trifluoromethyl groups, can participate in the reaction, providing a series of fipronil derivatives of 4-aryl-phenylpyrazole with potential bioactivity in moderate to good yields. All the compounds were characterized by 1H NMR, 13C NMR and HRMS ...