New continuous production process for enantiopure (2 R, 5 R)-hexanediol

J Haberland, W Hummel, T Daussmann…

Index: Haberland, Juergen; Hummel, Werner; Daussmann, Thomas; Liese, Andreas Organic Process Research and Development, 2002 , vol. 6, # 4 p. 458 - 462

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Citation Number: 54

Abstract

A new continuous production process has been developed for optically active pure (2 R, 5 R)-hexanediol. The process uses resting whole cells of Lactobacillus kefir DSM 20587 as a biocatalyst. The reduction of (2, 5)-hexanedione to (2 R, 5 R)-hexanediol was carried out in a 2-L continuously operated membrane reactor. Conversion of (2, 5)-hexanedione was nearly quantitative and the selectivity between product and intermediate was 78% for the ...