Organic letters

Twofold C− H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides

G Brasche, J Garcia-Fortanet, SL Buchwald

Index: Brasche, Gordon; Garcia-Fortanet, Jorge; Buchwald, Stephen L. Organic Letters, 2008 , vol. 10, # 11 p. 2207 - 2210

Full Text: HTML

Citation Number: 224

Abstract

The ortho arylation of anilides to form biphenyls via a twofold C− H functionalization/C− C bond-forming process is described. The oxidative coupling takes place in the presence of 5− 10 mol% of Pd (OAc) 2, 10− 20 mol% of DMSO, and 4− 11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.