A study of chemical carcinogenesis. 91. Reactions with deoxyguanosine of 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a model compound for. alpha.- …

…, D Lin, J Chuang, A Castonguay

Index: Hecht; Lin; Chuang; Castonguay Journal of the American Chemical Society, 1986 , vol. 108, # 6 p. 1292 - 1295

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Abstract

Abstract: 4-(3-Pyridyl)-4-oxobutanediazohydroxide (10) is a likely product of metabolic a- hydroxylation of the tobacco nitrosamines N'-nitrosonornicotine (2) and 4- (methylnitrosamino)-l-(3-pyridyl)-l-butanone (1). The reactions of 4-(carb-ethoxynitrosamino)- l-(3-pyridyl)-l-butanone (12), a stable precursor to 10, with deoxyguanosine and H20 at pH 8 were investigated. Three products of the reaction of 12 with deoxyguanosine were ...