A Novel N??(Pyrrolidinyl??2??methyl) glycine??Based PNA with a Strong Preference for RNA over DNA
A Slaitas, E Yeheskiely
Index: Slaitas, Andis; Yeheskiely, Esther European Journal of Organic Chemistry, 2002 , # 14 p. 2391 - 2399
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Citation Number: 19
Abstract
Abstract A novel, N-(pyrrolidinyl-2-methyl) glycine-based (Pmg-based) PNA is introduced. The synthesis of the backbone was accomplished in good yield, starting from prolinol. Thymine (S)-and (R)-Pmg and adenine-and cytosine-derived (R)-Pmg monomers were prepared. Five different fragments− two with either the (R) or the (S) isomer of the thymine Pmg monomer, two oligomers with two consecutive (R)-or (S)-thymine Pmg units, and fully ...
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