Steroids. CCVI. 1 Ring A Modified Hormone Analogs. Part II. 2-Methylene Androstanes and 2-Methyl-Δ1, Δ2 and Δ3-Androstenes2

AD Cross, JA Edwards, JC Orr, B Berköz…

Index: Cross,A.D. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 162 - 166

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Citation Number: 9

Abstract

l'lie cliscoi~ cry iii tlic aiidroatatie series that a C-;{osygeii sitbstitiiciit\ vas iiot an cssciitial prerecpisite of tiiological activity I-' Icd u:, to iiir-estigate" iioit-classical" aiidrostaiie structures in TI liicli the broader re-yiiircment of an elcctroii rich riiig. A was met hy tlw preseiicc of carboii-carlioii douhle Iioridb. In partic-ular it\ vas iioted that uusaturatioli at C-2 and ('-3 ill, or A3 olefiiis) wa:, compatiblc 11 itli a reasoiiahlc~ lc\-cl of biological activity.'[ti vie\ $* of the ...