Tetrahedron letters

Synthesis of C 2-symmetrical bis-β-amino alcohols and their application in the enantioselective addition of diethylzinc to aldehydes

Q Xu, H Wang, X Pan, ASC Chan, T Yang

Index: Xu, Qianyong; Wang, Hui; Pan, Xinfu; Chan, Albert S.C; Yang, Teng-Kuei Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6171 - 6173

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Citation Number: 33

Abstract

The C2-symmetrical bis-β-amino alcohols 1–6 were prepared and especially attention is focused on bridges, which link the two β-amino alcohol units. These ligands have been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. sec- Alcohols have been obtained in good yields with up to 95.4% enantiomeric excess.