Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors

…, C Tan, C Gao, C Zhang, X Luan, X Chen, H Liu…

Index: Li, Yunqi; Tan, Chunyan; Gao, Chunmei; Zhang, Cunlong; Luan, Xudong; Chen, Xiaowu; Liu, Hongxia; Chen, Yuzong; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 15 p. 4529 - 4535

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Citation Number: 38

Abstract

Multi-target EGFR, VEGFR-2 and PDGFR inhibitors are highly useful anticancer agents with improved therapeutic efficacies. In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series of benzimidazole derivatives, 2-aryl benzimidazole compounds, as multi-target EGFR, VEGFR-2 and PDGFR inhibitors. 2-Aryl benzimidazole compounds were synthesized and their biological ...