Discovery of α-amidosulfones as potent and selective agonists of CB 2: Synthesis, SAR, and pharmacokinetic properties

…, EF DiMauro, A Cheng, R Emkey, SA Hitchcock…

Index: Marx, Isaac E.; DiMauro, Erin F.; Cheng, Alan; Emkey, Renee; Hitchcock, Stephen A.; Huang, Liyue; Huang, Ming Y.; Human, Jason; Lee, Josie H.; Li, Xingwen; Martin, Matthew W.; White, Ryan D.; Fremeau Jr., Robert T.; Patel, Vinod F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 31 - 35

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Citation Number: 26

Abstract

A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure–activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.