Tetrahedron letters

Amino acid binding in water by a new guanidiniocarbonyl pyrrole dication: the effect of the experimental conditions on complex stability and stoichiometry

C Schmuck, S Graupner

Index: Schmuck, Carsten; Graupner, Svea Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1295 - 1298

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Citation Number: 19

Abstract

The synthesis and binding properties of a new guanidiniocarbonyl pyrrole dication are reported, which efficiently binds alanine carboxylate with logKass= 3.9 in buffered water. Due to the increased charge density in this dication, the binding constant is five times larger than for the parent guanidiniocarbonyl pyrrole monocation (logK= 3.2). However, the experimental conditions for determining the binding constant significantly influence both ...