Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues

…, JP Couty, MC Gershengorn, GR Marshall

Index: Zhang, Wei-Jun; Berglund, Anders; Kao, Jeff L.-F.; Couty, Jean-Pierre; Gershengorn, Marvin C.; Marshall, Garland R. Journal of the American Chemical Society, 2003 , vol. 125, # 5 p. 1221 - 1235

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Citation Number: 53

Abstract

The β-turn is a well-studied motif in both proteins and peptides. Four residues, making almost a complete 180°-turn in the direction of the peptide chain, define the β-turn. Several types of the β-turn are defined according to Φ and Ψ torsional angles of the backbone for residues i+ 1 and i+ 2. One special type of β-turn, the type VI-turn, usually contains a proline with a cis-amide bond at residue i+ 2. In an aza-amino acid, the α-carbon of the amino ...