Tetrahedron

Efficient microwave-assisted synthesis of new sulfonylbenzimidazole-4, 7-diones: Heterocyclic quinones with potential antitumor activity

N Boufatah, A Gellis, J Maldonado, P Vanelle

Index: Boufatah, Narimene; Gellis, Armand; Maldonado, Jose; Vanelle, Patrice Tetrahedron, 2004 , vol. 60, # 41 p. 9131 - 9137

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Citation Number: 64

Abstract

A great number of heterocyclic quinones have been extensively investigated for their biological activity and especially for their noticeable antitumor activity. Mitomycins 1, 2, 3 and 4 and the corresponding mitosenes (such as EO9 5 and many indole analogues 6 ) are well-known examples of reductive alkylating quinones (Scheme 1). The reductive alkylation process involves the formation of an alkylating quinone methide species upon reduction of the quinone and elimination ...