Characterization of mefenamic acid-guaiacol ester: stability and transport across Caco-2 cell monolayers

…, K Wiwattanawongsa, S Pinsuwan, S Kasiwong…

Index: Tantishaiyakul, Vimon; Wiwattanawongsa, Kamonthip; Pinsuwan, Sirirat; Kasiwong, Srirat; Phadoongsombut, Narubodee; Kaewnopparat, Sanae; Kaewnopparat, Nattha; Rojanasakul, Yon Pharmaceutical research, 2002 , vol. 19, # 7 p. 1013 - 1018

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Citation Number: 24

Abstract

Abstract Purpose. Prodrug of non-steroidal anti-inflammatory drugs (NSAIDs) or NSAIDs linked with guaiacol have been reported to suppress gastrointestinal (GI) toxicity or induce GI protective effect. In this study, mefenamic-guaiacol ester was synthesized and its physicochemical properties, stability, and transport across Caco-2 monolayers were investigated. Methods. Synthesis of the ester was carried out using mefenamic acid, ...