Isolation and structural elucidation of degradation products of alprazolam: photostability studies of alprazolam tablets

NS Nudelman, CG Cabrera

Index: Nudelman, Norma S.; Cabrera, C. Gallardo Journal of Pharmaceutical Sciences, 2002 , vol. 91, # 5 p. 1274 - 1286

Full Text: HTML

Citation Number: 23

Abstract

Abstract Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized as: triazolaminoquinoleine; 5-chloro- [5‵‵-methyl-4H-1, 2, 4-triazol-4-yl] benzophenone, and 1-methyl-6-phenyl-4H-s-triazo-[4 ...