Development of a Solid??Phase Approach to the Natural Product Class of Ahp??Containing Cyclodepsipeptides

SC Stolze, M Meltzer, M Ehrmann…

Index: Stolze, Sara C.; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus European Journal of Organic Chemistry, 2012 , # 8 p. 1616 - 1625

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Citation Number: 6

Abstract

Abstract The 3-amino-6-hydroxy-2-piperidone (Ahp) containing cyclodepsipeptides are an interesting class of natural products that inhibit S1 (trypsin and chymotrypsin-like) serine protease in a reversible, noncovalent manner, turning them into potential chemical tools for protease research. Their systematic use in chemical biology is however hampered by their tedious solution-phase chemical synthesis. To overcome this limitation, we report a solid- ...